<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by CompSci Transform (tm) - http://www.compsciresources.com -->
<!-- Created: Tue Nov 11 06:28:53 UTC 2025 -->
<xs:schema elementFormDefault="qualified" xmlns:srt-types="http://fasb.org/srt-types/2025" targetNamespace="http://orukatx.com/20250930" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:orka="http://orukatx.com/20250930" xmlns:us-types="http://fasb.org/us-types/2025" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dtr="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance">
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:type="simple" xlink:href="orka-20250930_lab.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="orka-20250930_pre.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="orka-20250930_def.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="orka-20250930_cal.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef"/>
      <link:roleType roleURI="http://orukatx.com/role/ConsolidatedBalanceSheet" id="orka_r_ConsolidatedBalanceSheet">
        <link:definition>995301 - Statement - Condensed Consolidated Balance Sheets (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ConsolidatedBalanceSheet_Parentheticals" id="orka_r_ConsolidatedBalanceSheet_Parentheticals">
        <link:definition>995302 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parentheticals)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ConsolidatedComprehensiveIncome" id="orka_r_ConsolidatedComprehensiveIncome">
        <link:definition>995303 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ConsolidatedComprehensiveIncome_Parentheticals" id="orka_r_ConsolidatedComprehensiveIncome_Parentheticals">
        <link:definition>995304 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) (Parentheticals)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ShareholdersEquityType2or3" id="orka_r_ShareholdersEquityType2or3">
        <link:definition>995305 - Statement - Condensed Consolidated Statements of Convertible Preferred Stock and Stockholders&#8217; Equity (Deficit) (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ShareholdersEquityType2or3_Parentheticals" id="orka_r_ShareholdersEquityType2or3_Parentheticals">
        <link:definition>995306 - Statement - Condensed Consolidated Statements of Convertible Preferred Stock and Stockholders&#8217; Equity (Deficit) (Unaudited) (Parentheticals)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ConsolidatedCashFlow" id="orka_r_ConsolidatedCashFlow">
        <link:definition>995307 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/NatureoftheBusinessandBasisofPresentation" id="orka_r_NatureoftheBusinessandBasisofPresentation">
        <link:definition>995308 - Disclosure - Nature of the Business and Basis of Presentation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/SummaryofSignificantAccountingPolicies" id="orka_r_SummaryofSignificantAccountingPolicies">
        <link:definition>995309 - Disclosure - Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/FairValueMeasurements" id="orka_r_FairValueMeasurements">
        <link:definition>995310 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/CashEquivalentsandMarketableSecurities" id="orka_r_CashEquivalentsandMarketableSecurities">
        <link:definition>995311 - Disclosure - Cash Equivalents and Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/AccruedExpensesandOtherCurrentLiabilities" id="orka_r_AccruedExpensesandOtherCurrentLiabilities">
        <link:definition>995312 - Disclosure - Accrued Expenses and Other Current Liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/NotePayablewithRelatedParty" id="orka_r_NotePayablewithRelatedParty">
        <link:definition>995313 - Disclosure - Note Payable with Related Party</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ConvertiblePreferredStockandStockholdersEquity" id="orka_r_ConvertiblePreferredStockandStockholdersEquity">
        <link:definition>995314 - Disclosure - Convertible Preferred Stock and Stockholders&#8217; Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/StockBasedCompensation" id="orka_r_StockBasedCompensation">
        <link:definition>995315 - Disclosure - Stock-Based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/SegmentDisclosures" id="orka_r_SegmentDisclosures">
        <link:definition>995316 - Disclosure - Segment Disclosures</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/OptionAgreementsandLicenseAgreements" id="orka_r_OptionAgreementsandLicenseAgreements">
        <link:definition>995317 - Disclosure - Option Agreements and License Agreements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/CommitmentsandContingencies" id="orka_r_CommitmentsandContingencies">
        <link:definition>995318 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/NetLossPerShare" id="orka_r_NetLossPerShare">
        <link:definition>995319 - Disclosure - Net Loss Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/RelatedPartyTransactions" id="orka_r_RelatedPartyTransactions">
        <link:definition>995320 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/IncomeTaxes" id="orka_r_IncomeTaxes">
        <link:definition>995321 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/AccountingPoliciesByPolicy" id="orka_r_AccountingPoliciesByPolicy">
        <link:definition>996000 - Disclosure - Accounting Policies, by Policy (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/FairValueMeasurementsTables" id="orka_r_FairValueMeasurementsTables">
        <link:definition>996001 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/CashEquivalentsandMarketableSecuritiesTables" id="orka_r_CashEquivalentsandMarketableSecuritiesTables">
        <link:definition>996002 - Disclosure - Cash Equivalents and Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/AccruedExpensesandOtherCurrentLiabilitiesTables" id="orka_r_AccruedExpensesandOtherCurrentLiabilitiesTables">
        <link:definition>996003 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ConvertiblePreferredStockandStockholdersEquityTables" id="orka_r_ConvertiblePreferredStockandStockholdersEquityTables">
        <link:definition>996004 - Disclosure - Convertible Preferred Stock and Stockholders&#8217; Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/StockBasedCompensationTables" id="orka_r_StockBasedCompensationTables">
        <link:definition>996005 - Disclosure - Stock-Based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/SegmentDisclosuresTables" id="orka_r_SegmentDisclosuresTables">
        <link:definition>996006 - Disclosure - Segment Disclosures (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/CommitmentsandContingenciesTables" id="orka_r_CommitmentsandContingenciesTables">
        <link:definition>996007 - Disclosure - Commitments and Contingencies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/NetLossPerShareTables" id="orka_r_NetLossPerShareTables">
        <link:definition>996008 - Disclosure - Net Loss Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/RelatedPartyTransactionsTables" id="orka_r_RelatedPartyTransactionsTables">
        <link:definition>996009 - Disclosure - Related Party Transactions (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/NatureoftheBusinessandBasisofPresentationDetails" id="orka_r_NatureoftheBusinessandBasisofPresentationDetails">
        <link:definition>996010 - Disclosure - Nature of the Business and Basis of Presentation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofFairValueHierarchyforFinancialAssetsMeasuredTable" id="orka_r_ScheduleofFairValueHierarchyforFinancialAssetsMeasuredTable">
        <link:definition>996011 - Disclosure - Fair Value Measurements - Schedule of Fair Value Hierarchy for Financial Assets Measured (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofCashEquivalentsandMarketableSecuritiesTable" id="orka_r_ScheduleofCashEquivalentsandMarketableSecuritiesTable">
        <link:definition>996012 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Cash Equivalents and Marketable Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofAvailableforSaleSecuritiesinanUnrealizedLossPositionTable" id="orka_r_ScheduleofAvailableforSaleSecuritiesinanUnrealizedLossPositionTable">
        <link:definition>996013 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Available-for-Sale Securities in an Unrealized Loss Position (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofMarketableSecuritiesatEstimatedFairValueTable" id="orka_r_ScheduleofMarketableSecuritiesatEstimatedFairValueTable">
        <link:definition>996014 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Marketable Securities at Estimated Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofAccruedExpensesandOtherCurrentLiabilitiesTable" id="orka_r_ScheduleofAccruedExpensesandOtherCurrentLiabilitiesTable">
        <link:definition>996015 - Disclosure - Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/NotePayablewithRelatedPartyDetails" id="orka_r_NotePayablewithRelatedPartyDetails">
        <link:definition>996016 - Disclosure - Note Payable with Related Party (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ConvertiblePreferredStockandStockholdersEquityDetails" id="orka_r_ConvertiblePreferredStockandStockholdersEquityDetails">
        <link:definition>996017 - Disclosure - Convertible Preferred Stock and Stockholders&#8217; Equity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofPreferredStockTable" id="orka_r_ScheduleofPreferredStockTable">
        <link:definition>996018 - Disclosure - Convertible Preferred Stock and Stockholders&#8217; Equity - Schedule of Preferred Stock (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofCommonStockReservedforFutureIssuanceTable" id="orka_r_ScheduleofCommonStockReservedforFutureIssuanceTable">
        <link:definition>996019 - Disclosure - Convertible Preferred Stock and Stockholders&#8217; Equity - Schedule of Common Stock Reserved for Future Issuance (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/StockBasedCompensationDetails" id="orka_r_StockBasedCompensationDetails">
        <link:definition>996020 - Disclosure - Stock-Based Compensation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofWeightedAverageAssumptionsUsedinCalculatingtheFairValueoftheAwardsTable" id="orka_r_ScheduleofWeightedAverageAssumptionsUsedinCalculatingtheFairValueoftheAwardsTable">
        <link:definition>996021 - Disclosure - Stock-Based Compensation - Schedule of Weighted-Average Assumptions Used in Calculating the Fair Value of the Awards (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofStockOptionActivityTable" id="orka_r_ScheduleofStockOptionActivityTable">
        <link:definition>996022 - Disclosure - Stock-Based Compensation - Schedule of Stock Option Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofRSAActivityTable" id="orka_r_ScheduleofRSAActivityTable">
        <link:definition>996023 - Disclosure - Stock-Based Compensation - Schedule of RSA Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofEmployeeWarrantActivityTable" id="orka_r_ScheduleofEmployeeWarrantActivityTable">
        <link:definition>996024 - Disclosure - Stock-Based Compensation - Schedule of Employee Warrant Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofCompanysStockBasedCompensationExpenseTable" id="orka_r_ScheduleofCompanysStockBasedCompensationExpenseTable">
        <link:definition>996025 - Disclosure - Stock-Based Compensation - Schedule of Company&#8217;s Stock-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofAwardTypesofCompanysStockBasedCompensationExpenseTable" id="orka_r_ScheduleofAwardTypesofCompanysStockBasedCompensationExpenseTable">
        <link:definition>996026 - Disclosure - Stock-Based Compensation - Schedule of Award Types of Company&#8217;s Stock-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/SegmentDisclosuresDetails" id="orka_r_SegmentDisclosuresDetails">
        <link:definition>996027 - Disclosure - Segment Disclosures (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofSegmentLossfromOperationsTable" id="orka_r_ScheduleofSegmentLossfromOperationsTable">
        <link:definition>996028 - Disclosure - Segment Disclosures - Schedule of Segment Loss from Operations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/OptionAgreementsandLicenseAgreementsDetails" id="orka_r_OptionAgreementsandLicenseAgreementsDetails">
        <link:definition>996029 - Disclosure - Option Agreements and License Agreements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/CommitmentsandContingenciesDetails" id="orka_r_CommitmentsandContingenciesDetails">
        <link:definition>996030 - Disclosure - Commitments and Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofCompanysSupplementalCashFlowInformationRelatedtoLeasesTable" id="orka_r_ScheduleofCompanysSupplementalCashFlowInformationRelatedtoLeasesTable">
        <link:definition>996031 - Disclosure - Commitments and Contingencies - Schedule of Company&#8217;s Supplemental Cash Flow Information Related to Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofCompanysOperatingLeaseLiabilitiesShowingtheAggregateLeasePaymentsTable" id="orka_r_ScheduleofCompanysOperatingLeaseLiabilitiesShowingtheAggregateLeasePaymentsTable">
        <link:definition>996032 - Disclosure - Commitments and Contingencies - Schedule of Company&#8217;s Operating Lease Liabilities Showing the Aggregate Lease Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/NetLossPerShareDetails" id="orka_r_NetLossPerShareDetails">
        <link:definition>996033 - Disclosure - Net Loss Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofBasicandDilutedNetLossPerShareAttributabletoStockholdersTable" id="orka_r_ScheduleofBasicandDilutedNetLossPerShareAttributabletoStockholdersTable">
        <link:definition>996034 - Disclosure - Net Loss Per Share - Schedule of Basic and Diluted Net Loss Per Share Attributable to Stockholders (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofAntiDilutiveEffectExcludedfromPotentialComputationofDilutedNetLossPerShareTable" id="orka_r_ScheduleofAntiDilutiveEffectExcludedfromPotentialComputationofDilutedNetLossPerShareTable">
        <link:definition>996035 - Disclosure - Net Loss Per Share - Schedule of Anti-Dilutive Effect Excluded from Potential Computation of Diluted Net Loss Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/RelatedPartyTransactionsDetails" id="orka_r_RelatedPartyTransactionsDetails">
        <link:definition>996036 - Disclosure - Related Party Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/ScheduleofRelatedPartyAccountsPayableandOtherCurrentLiabilitiesTable" id="orka_r_ScheduleofRelatedPartyAccountsPayableandOtherCurrentLiabilitiesTable">
        <link:definition>996037 - Disclosure - Related Party Transactions - Schedule of Related Party Accounts Payable and Other Current Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/IncomeTaxesDetails" id="orka_r_IncomeTaxesDetails">
        <link:definition>996038 - Disclosure - Income Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://orukatx.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
        <link:definition>000 - Document - Document And Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://fasb.org/us-types/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-types-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://fasb.org/srt-types/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-types-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/sic/2025" schemaLocation="https://xbrl.sec.gov/sic/2025/sic-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei-sub/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-sub-2025.xsd"/>
  <xs:element name="JoanaGoncalvesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_JoanaGoncalvesMember"/>
  <xs:element name="LauraSandlerMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_LauraSandlerMember"/>
  <xs:element name="ScheduleOfFairValueHierarchyForFinancialAssetsMeasuredAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfFairValueHierarchyForFinancialAssetsMeasuredAbstract"/>
  <xs:element name="ScheduleOfCashEquivalentsAndMarketableSecuritiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfCashEquivalentsAndMarketableSecuritiesAbstract"/>
  <xs:element name="ScheduleOfAvailableForSaleSecuritiesInAnUnrealizedLossPositionAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfAvailableForSaleSecuritiesInAnUnrealizedLossPositionAbstract"/>
  <xs:element name="ScheduleOfPreferredStockAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfPreferredStockAbstract"/>
  <xs:element name="ScheduleOfCommonStockReservedForFutureIssuanceAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfCommonStockReservedForFutureIssuanceAbstract"/>
  <xs:element name="ScheduleOfWeightedAverageAssumptionsUsedInCalculatingTheFairValueOfTheAwardsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfWeightedAverageAssumptionsUsedInCalculatingTheFairValueOfTheAwardsAbstract"/>
  <xs:element name="ScheduleOfRsaActivityAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfRsaActivityAbstract"/>
  <xs:element name="ScheduleOfEmployeeWarrantActivityAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfEmployeeWarrantActivityAbstract"/>
  <xs:element name="ScheduleOfCompanySStockBasedCompensationExpenseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfCompanySStockBasedCompensationExpenseAbstract"/>
  <xs:element name="ScheduleOfAwardTypesOfCompanySStockBasedCompensationExpenseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfAwardTypesOfCompanySStockBasedCompensationExpenseAbstract"/>
  <xs:element name="ScheduleOfSegmentLossFromOperationsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfSegmentLossFromOperationsAbstract"/>
  <xs:element name="ScheduleOfBasicAndDilutedNetLossPerShareAttributableToStockholdersAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfBasicAndDilutedNetLossPerShareAttributableToStockholdersAbstract"/>
  <xs:element name="ScheduleOfAntiDilutiveEffectExcludedFromPotentialComputationOfDilutedNetLossPerShareAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfAntiDilutiveEffectExcludedFromPotentialComputationOfDilutedNetLossPerShareAbstract"/>
  <xs:element name="ScheduleOfRelatedPartyAccountsPayableAndOtherCurrentLiabilitiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfRelatedPartyAccountsPayableAndOtherCurrentLiabilitiesAbstract"/>
  <xs:element name="MarketableSecuritiesCurrentAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesCurrentAbstract"/>
  <xs:element name="MarketableSecuritiesLongTermAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesLongTermAbstract"/>
  <xs:element name="MarketableSecuritiesAbstract0" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesAbstract0"/>
  <xs:element name="MarketableSecuritiesCurrentAbstract0" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesCurrentAbstract0"/>
  <xs:element name="MarketableSecuritiesLongTermAbstract0" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesLongTermAbstract0"/>
  <xs:element name="MarketableSecuritiesCurrentAbstract1" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesCurrentAbstract1"/>
  <xs:element name="MarketableSecuritiesCurrentAbstract2" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesCurrentAbstract2"/>
  <xs:element name="StockIssuedDuringPeriodIssuanceOfCommonStockAndPrefundedWarrantsInConnectionWithThe2025PIPEFinancing" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_StockIssuedDuringPeriodIssuanceOfCommonStockAndPrefundedWarrantsInConnectionWithThe2025PIPEFinancing"/>
  <xs:element name="ShockIssuedDuringPeriodSharesIssuanceOfCommonStockAndPrefundedWarrantsInConnectionWithThe2025PIPEFinancing" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ShockIssuedDuringPeriodSharesIssuanceOfCommonStockAndPrefundedWarrantsInConnectionWithThe2025PIPEFinancing"/>
  <xs:element name="IssuanceCostOf2025PIPEFinancing" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_IssuanceCostOf2025PIPEFinancing"/>
  <xs:element name="TempororyEquityIssuedDuringPeriodValueExchangeOfSeriesAConvertiblePreferredStockForSeriesBNonvotingConvertiblePreferredStockForSeriesBNonVotingConvertiblePreferredStockReverseRecapitalization" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_TempororyEquityIssuedDuringPeriodValueExchangeOfSeriesAConvertiblePreferredStockForSeriesBNonvotingConvertiblePreferredStockForSeriesBNonVotingConvertiblePreferredStockReverseRecapitalization"/>
  <xs:element name="TempororyEquityIssuedDuringPeriodSharesExchangeOfSeriesAConvertiblePreferredStockForSeriesBNonvotingConvertiblePreferredStockforSeriesBNonVotingConvertiblePreferredStockReverseRecapitalization" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_TempororyEquityIssuedDuringPeriodSharesExchangeOfSeriesAConvertiblePreferredStockForSeriesBNonvotingConvertiblePreferredStockforSeriesBNonVotingConvertiblePreferredStockReverseRecapitalization"/>
  <xs:element name="StockIssuedDuringPeriodValueIssuanceOfCommonStockAndPrefundedWarrantsInThePreClosingFinancing" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_StockIssuedDuringPeriodValueIssuanceOfCommonStockAndPrefundedWarrantsInThePreClosingFinancing"/>
  <xs:element name="StockIssuedDuringPeriodValueIssuanceOfCommonStockToFormerStockholdersOfARCABiopharmaIncInConnectionWithTheReverseRecapitalization" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_StockIssuedDuringPeriodValueIssuanceOfCommonStockToFormerStockholdersOfARCABiopharmaIncInConnectionWithTheReverseRecapitalization"/>
  <xs:element name="StockIssuedDuringPeriodSharesIssuanceOfCommonStockToFormerStockholdersOfARCABiopharmaIncInConnectionWithTheclosingOfEeverseRecapitalization" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_StockIssuedDuringPeriodSharesIssuanceOfCommonStockToFormerStockholdersOfARCABiopharmaIncInConnectionWithTheclosingOfEeverseRecapitalization"/>
  <xs:element name="StockIssuedDuringPeriodValueIssuanceOfCommonStockSeriesANonvotingConvertiblePreferredStockAndPrefundedWarrantsInConnectionWith2024PIPEFinancing" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_StockIssuedDuringPeriodValueIssuanceOfCommonStockSeriesANonvotingConvertiblePreferredStockAndPrefundedWarrantsInConnectionWith2024PIPEFinancing"/>
  <xs:element name="StockIssuedDuringPeriodSharesIssuanceOfCommonStockSeriesANonvotingConvertiblePreferredStockAndPrefundedWarrantsInConnectionWith2024PIPEFinancing" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_StockIssuedDuringPeriodSharesIssuanceOfCommonStockSeriesANonvotingConvertiblePreferredStockAndPrefundedWarrantsInConnectionWith2024PIPEFinancing"/>
  <xs:element name="IssuanceCostOf2024PIPEFinancing" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_IssuanceCostOf2024PIPEFinancing"/>
  <xs:element name="TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues"/>
  <xs:element name="ProceedsFromThePIPEFinancingNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_ProceedsFromThePIPEFinancingNet"/>
  <xs:element name="ProceedsFromCashAcquiredInConnectionWithTheReverseRecapitalization" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_ProceedsFromCashAcquiredInConnectionWithTheReverseRecapitalization"/>
  <xs:element name="PreClosingFinancingAndReverseRecapitalizationIssuanceCostsIncludedInAccountsPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_PreClosingFinancingAndReverseRecapitalizationIssuanceCostsIncludedInAccountsPayable"/>
  <xs:element name="PIPEFinancingIssuanceCostsIncludedInAccountsPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_PIPEFinancingIssuanceCostsIncludedInAccountsPayable"/>
  <xs:element name="PIPEFinancingIssuanceCostsIncludedInAccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_PIPEFinancingIssuanceCostsIncludedInAccruedExpensesAndOtherCurrentLiabilities"/>
  <xs:element name="NoncashAccruedInterestOnConvertibleNoteConvertedToCommonStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_NoncashAccruedInterestOnConvertibleNoteConvertedToCommonStock"/>
  <xs:element name="OptionAgreementsAndLicenseAgreementsTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OptionAgreementsAndLicenseAgreementsTextBlock"/>
  <xs:element name="ScheduleOfConvertiblePreferredStockTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfConvertiblePreferredStockTableTextBlock"/>
  <xs:element name="ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock"/>
  <xs:element name="ShareBasedPaymentArrangementWarrantActivityTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedPaymentArrangementWarrantActivityTableTextBlock"/>
  <xs:element name="FairValueMeasurementsScheduleofFairValueHierarchyforFinancialAssetsMeasuredDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_FairValueMeasurementsScheduleofFairValueHierarchyforFinancialAssetsMeasuredDetailsTable"/>
  <xs:element name="MarketableSecuritiesDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesDomainDomain"/>
  <xs:element name="AccruedResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_AccruedResearchAndDevelopment"/>
  <xs:element name="ConvertiblePreferredStockandStockholdersEquityScheduleofPreferredStockDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_ConvertiblePreferredStockandStockholdersEquityScheduleofPreferredStockDetailsTable"/>
  <xs:element name="ConvertiblePreferredStockandStockholdersEquityScheduleofCommonStockReservedforFutureIssuanceDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_ConvertiblePreferredStockandStockholdersEquityScheduleofCommonStockReservedforFutureIssuanceDetailsTable"/>
  <xs:element name="StockBasedCompensationScheduleofWeightedAverageAssumptionsUsedinCalculatingtheFairValueoftheAwardsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_StockBasedCompensationScheduleofWeightedAverageAssumptionsUsedinCalculatingtheFairValueoftheAwardsDetailsTable"/>
  <xs:element name="StockBasedCompensationScheduleofRSAActivityDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_StockBasedCompensationScheduleofRSAActivityDetailsTable"/>
  <xs:element name="StockBasedCompensationScheduleofEmployeeWarrantActivityDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_StockBasedCompensationScheduleofEmployeeWarrantActivityDetailsTable"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercised"/>
  <xs:element name="WeightedAverageShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriodWeightedAverageExercisePricePerShareExercised" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_WeightedAverageShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriodWeightedAverageExercisePricePerShareExercised"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedExpectedToVestOutstandingNumber" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedExpectedToVestOutstandingNumber"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsVestedAndExpectedToVestWeightedAverageExercisePrice" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsVestedAndExpectedToVestWeightedAverageExercisePrice"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestWeightedAverageRemainingContractualTerm"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVest" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVest"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsVestedAndExercisableOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsVestedAndExercisableOutstanding"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsVestedAndExercisableWeightedAverageExercisePrice" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsVestedAndExercisableWeightedAverageExercisePrice"/>
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisableWeightedAverageRemainingContractualTermVestedAndExercisable" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisableWeightedAverageRemainingContractualTermVestedAndExercisable"/>
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueVestedAndExercisable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueVestedAndExercisable"/>
  <xs:element name="StockBasedCompensationScheduleofAwardTypesofCompanysStockBasedCompensationExpenseDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_StockBasedCompensationScheduleofAwardTypesofCompanysStockBasedCompensationExpenseDetailsTable"/>
  <xs:element name="NetLossPerShareScheduleofBasicandDilutedNetLossPerShareAttributabletoStockholdersDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_NetLossPerShareScheduleofBasicandDilutedNetLossPerShareAttributabletoStockholdersDetailsTable"/>
  <xs:element name="NatureoftheBusinessandBasisofPresentationDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_NatureoftheBusinessandBasisofPresentationDetailsTable"/>
  <xs:element name="AdditionalPaidInCapitalTransactionCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_AdditionalPaidInCapitalTransactionCost"/>
  <xs:element name="ExchangeRatio" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ExchangeRatio"/>
  <xs:element name="CommonStocksConversionRatio" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_CommonStocksConversionRatio"/>
  <xs:element name="NumberOfSharesPurchased" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_NumberOfSharesPurchased"/>
  <xs:element name="NumberofAggregateShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_NumberofAggregateShares"/>
  <xs:element name="PrefundedWarrantstoPurchaseAnAggregateShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PrefundedWarrantstoPurchaseAnAggregateShares"/>
  <xs:element name="NotePayablewithRelatedPartyDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_NotePayablewithRelatedPartyDetailsTable"/>
  <xs:element name="ConvertiblePreferredStockandStockholdersEquityDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_ConvertiblePreferredStockandStockholdersEquityDetailsTable"/>
  <xs:element name="ClassOfWarrantsExercisable" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ClassOfWarrantsExercisable"/>
  <xs:element name="ClassOfWarrantOrRightExpirationDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ClassOfWarrantOrRightExpirationDate"/>
  <xs:element name="CommonStockConversionRatio" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_CommonStockConversionRatio"/>
  <xs:element name="WarrantsToPurchaseCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_WarrantsToPurchaseCommonStock"/>
  <xs:element name="StockBasedCompensationDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_StockBasedCompensationDetailsTable"/>
  <xs:element name="ShareBasedCompensationArrangementAnnualIncreaseInNumberOfCommonStockSharesReservedForFutureIssuance" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementAnnualIncreaseInNumberOfCommonStockSharesReservedForFutureIssuance"/>
  <xs:element name="EmployeeStockPurchasePlanESPPCashContributionsToESPP" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_EmployeeStockPurchasePlanESPPCashContributionsToESPP"/>
  <xs:element name="ClassOfWarrantOrRightToPurchasePercentageOfOutstandingDilutedStockMaximum" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ClassOfWarrantOrRightToPurchasePercentageOfOutstandingDilutedStockMaximum"/>
  <xs:element name="EstimatedFairValueOfWarrantsToBeGranted" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_EstimatedFairValueOfWarrantsToBeGranted"/>
  <xs:element name="ClassOfWarrantOrRight" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ClassOfWarrantOrRight"/>
  <xs:element name="OptionAgreementsandLicenseAgreementsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_OptionAgreementsandLicenseAgreementsDetailsTable"/>
  <xs:element name="NonRefundableMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_NonRefundableMilestonePayments"/>
  <xs:element name="RoyaltyPayableOnProductSales" type="xbrli:stringItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_RoyaltyPayableOnProductSales"/>
  <xs:element name="NonRefundableInitiationFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_NonRefundableInitiationFee"/>
  <xs:element name="MilestoneConsiderationPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_MilestoneConsiderationPaid"/>
  <xs:element name="DevelopmentCost" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_DevelopmentCost"/>
  <xs:element name="MilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_MilestonePayment"/>
  <xs:element name="CommitmentsandContingenciesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_CommitmentsandContingenciesDetailsTable"/>
  <xs:element name="NonRefundableLicenseFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_NonRefundableLicenseFee"/>
  <xs:element name="NetLossPerShareDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_NetLossPerShareDetailsTable"/>
  <xs:element name="RelatedPartyTransactionsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_RelatedPartyTransactionsDetailsTable"/>
  <xs:element name="DescriptionOfMinorityInterestOwnershipPercentageByNoncontrollingOwners" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_DescriptionOfMinorityInterestOwnershipPercentageByNoncontrollingOwners"/>
  <xs:element name="IncomeTaxesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_IncomeTaxesDetailsTable"/>
  <xs:element name="BonusDepreciation" type="dtr:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_BonusDepreciation"/>
  <xs:element name="MarketableSecuritiesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="orka_MarketableSecuritiesAxis"/>
  <xs:element name="ARCAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ARCAMember"/>
  <xs:element name="ARCASeriesBNonvotingConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ARCASeriesBNonvotingConvertiblePreferredStockMember"/>
  <xs:element name="AchievementOfDevelopmentCandidateMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_AchievementOfDevelopmentCandidateMember"/>
  <xs:element name="AllocatedShareBasedCompensationExpenseMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_AllocatedShareBasedCompensationExpenseMember"/>
  <xs:element name="AntibodyProductsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_AntibodyProductsMember"/>
  <xs:element name="AtTheMarketOfferingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_AtTheMarketOfferingMember"/>
  <xs:element name="ClinicalDevelopmentMilestonesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ClinicalDevelopmentMilestonesMember"/>
  <xs:element name="ConvertibleNoteMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ConvertibleNoteMember"/>
  <xs:element name="EmployeeStockPurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_EmployeeStockPurchasePlanMember"/>
  <xs:element name="EmployeeWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_EmployeeWarrantsMember"/>
  <xs:element name="ExercisingOptionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ExercisingOptionMember"/>
  <xs:element name="ExternalMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ExternalMember"/>
  <xs:element name="FairmountHealthcareFundIILPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_FairmountHealthcareFundIILPMember"/>
  <xs:element name="FairmountMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_FairmountMember"/>
  <xs:element name="FirstDosingOfHumanPatientInPhaseOneTrialMilestoneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_FirstDosingOfHumanPatientInPhaseOneTrialMilestoneMember"/>
  <xs:element name="MarketableSecuritiesCurrentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesCurrentMember"/>
  <xs:element name="MarketableSecuritiesLongTermMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesLongTermMember"/>
  <xs:element name="MarketableSecuritiesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesMember"/>
  <xs:element name="MarketableSecuritiesNoncurrentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesNoncurrentMember"/>
  <xs:element name="ORKAZeroZeroOneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ORKAZeroZeroOneMember"/>
  <xs:element name="ORKAZeroZeroTwoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ORKAZeroZeroTwoMember"/>
  <xs:element name="OperatingExpenseExcludingPersonnelRelatedAndStockBasedCompensationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OperatingExpenseExcludingPersonnelRelatedAndStockBasedCompensationMember"/>
  <xs:element name="OperatingExpenseExcludingStockBasedCompensationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OperatingExpenseExcludingStockBasedCompensationMember"/>
  <xs:element name="OptionAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OptionAgreementMember"/>
  <xs:element name="OrukaCommonStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OrukaCommonStockMember"/>
  <xs:element name="OrukaSeriesAConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OrukaSeriesAConvertiblePreferredStockMember"/>
  <xs:element name="OtherMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OtherMember"/>
  <xs:element name="PIPEFinancingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PIPEFinancingMember"/>
  <xs:element name="ParagonMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonMember"/>
  <xs:element name="ParagonMilestonePaymentsForLicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonMilestonePaymentsForLicenseAgreementMember"/>
  <xs:element name="ParagonReimbursableOptionAgreementsFeesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonReimbursableOptionAgreementsFeesMember"/>
  <xs:element name="ParagonReimbursableOtherResearchExpensesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonReimbursableOtherResearchExpensesMember"/>
  <xs:element name="ParagonReimbursablePatentExpensesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonReimbursablePatentExpensesMember"/>
  <xs:element name="ParukaMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParukaMember"/>
  <xs:element name="ParukaWarrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParukaWarrantMember"/>
  <xs:element name="ParukaWarrantObligationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParukaWarrantObligationMember"/>
  <xs:element name="PreFundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PreFundedWarrantsMember"/>
  <xs:element name="PreMergerOrukaMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PreMergerOrukaMember"/>
  <xs:element name="PrefundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PrefundedWarrantsMember"/>
  <xs:element name="RegulatoryMilestonesMemberMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_RegulatoryMilestonesMemberMember"/>
  <xs:element name="RestrictedStockAwardsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_RestrictedStockAwardsMember"/>
  <xs:element name="SeriesANonVotingConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesANonVotingConvertiblePreferredStockMember"/>
  <xs:element name="SeriesANonVotingConvertiblePreferredStockholdersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesANonVotingConvertiblePreferredStockholdersMember"/>
  <xs:element name="SeriesBConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesBConvertiblePreferredStockMember"/>
  <xs:element name="SeriesBNonVotingConvertiblePreferredStockAmountMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesBNonVotingConvertiblePreferredStockAmountMember"/>
  <xs:element name="SeriesBNonVotingConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesBNonVotingConvertiblePreferredStockMember"/>
  <xs:element name="SeriesBNonVotingConvertiblePreferredStockholdersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesBNonVotingConvertiblePreferredStockholdersMember"/>
  <xs:element name="StockOptionsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_StockOptionsMember"/>
  <xs:element name="TwoThousandTwentyFourEmployeeStockPurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_TwoThousandTwentyFourEmployeeStockPurchasePlanMember"/>
  <xs:element name="TwoThousandTwentyFourStockIncentivePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_TwoThousandTwentyFourStockIncentivePlanMember"/>
  <xs:element name="TwoZeroTwoFourEmployeeStockPurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_TwoZeroTwoFourEmployeeStockPurchasePlanMember"/>
  <xs:element name="USGovernmentAgencySecuritiesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_USGovernmentAgencySecuritiesMember"/>
  <xs:element name="OptionAgreementsAndLicenseAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OptionAgreementsAndLicenseAgreementsAbstract"/>
<!-- [WMV6][/dF+bHbYNQjz034dM2rIMHCl9ENwgaMUqAMe2Tl3uQ+Sw1UOiVokuA4JCH+aVe32fTFcpvQIncliA7CP+o9hlVX5W7IwIzq4jWjIIUneSxZXCjdxHiIdlHuEpov8lVY4fxluq8PE/vHLHr5pfaIKeIXlaiPDywPyjqbwVsk0lmgYazJ8jLFM3XPxdaeAbb6k5Li3IaACF7XyPrYJjmQ/mVt2+YpPmc0boCDn9lFGKCCoiDyVFuhF+uPq9QpQg/okOaT5F50W2VJfYCr7N0HuZJ0hSIdWeCbQzG7/eeN2aAWNnd64XYbFePfeuOj4jOP9D/YjytvvlYwcRu8n1ed+qCJQf8mNpODnnDlxUmF/Fg==] CSR-->
  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_DocumentAndEntityInformationAbstract"/>
</xs:schema>
