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  <xs:element name="WarrantsToPurchaseCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_WarrantsToPurchaseCommonStock"/>
  <xs:element name="StockBasedCompensationDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_StockBasedCompensationDetailsTable"/>
  <xs:element name="ShareBasedCompensationArrangementAnnualIncreaseInNumberOfCommonStockSharesReservedForFutureIssuance" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ShareBasedCompensationArrangementAnnualIncreaseInNumberOfCommonStockSharesReservedForFutureIssuance"/>
  <xs:element name="EmployeeStockPurchasePlanESPPCashContributionsToESPP" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_EmployeeStockPurchasePlanESPPCashContributionsToESPP"/>
  <xs:element name="ClassOfWarrantOrRightToPurchasePercentageOfOutstandingDilutedStockMaximum" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ClassOfWarrantOrRightToPurchasePercentageOfOutstandingDilutedStockMaximum"/>
  <xs:element name="EstimatedFairValueOfWarrantsToBeGranted" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_EstimatedFairValueOfWarrantsToBeGranted"/>
  <xs:element name="ClassOfWarrantOrRight" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ClassOfWarrantOrRight"/>
  <xs:element name="OptionAgreementsandLicenseAgreementsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_OptionAgreementsandLicenseAgreementsDetailsTable"/>
  <xs:element name="NonRefundableMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_NonRefundableMilestonePayments"/>
  <xs:element name="RoyaltyPayableOnProductSales" type="xbrli:stringItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_RoyaltyPayableOnProductSales"/>
  <xs:element name="NonRefundableInitiationFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_NonRefundableInitiationFee"/>
  <xs:element name="MilestoneConsiderationPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="orka_MilestoneConsiderationPaid"/>
  <xs:element name="DevelopmentCost" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_DevelopmentCost"/>
  <xs:element name="CommitmentsandContingenciesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_CommitmentsandContingenciesDetailsTable"/>
  <xs:element name="NonRefundableLicenseFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="orka_NonRefundableLicenseFee"/>
  <xs:element name="NetLossPerShareDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_NetLossPerShareDetailsTable"/>
  <xs:element name="RelatedPartyTransactionsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_RelatedPartyTransactionsDetailsTable"/>
  <xs:element name="DescriptionOfMinorityInterestOwnershipPercentageByNoncontrollingOwners" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_DescriptionOfMinorityInterestOwnershipPercentageByNoncontrollingOwners"/>
  <xs:element name="IncomeTaxesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="orka_IncomeTaxesDetailsTable"/>
  <xs:element name="BonusDepreciation" type="dtr:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="orka_BonusDepreciation"/>
  <xs:element name="MarketableSecuritiesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="orka_MarketableSecuritiesAxis"/>
  <xs:element name="ARCAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ARCAMember"/>
  <xs:element name="ARCASeriesBNonvotingConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ARCASeriesBNonvotingConvertiblePreferredStockMember"/>
  <xs:element name="AchievementOfDevelopmentCandidateMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_AchievementOfDevelopmentCandidateMember"/>
  <xs:element name="AllocatedShareBasedCompensationExpenseMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_AllocatedShareBasedCompensationExpenseMember"/>
  <xs:element name="AntibodyProductsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_AntibodyProductsMember"/>
  <xs:element name="ClinicalDevelopmentMilestonesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ClinicalDevelopmentMilestonesMember"/>
  <xs:element name="ConvertibleNoteMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ConvertibleNoteMember"/>
  <xs:element name="EmployeeStockPurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_EmployeeStockPurchasePlanMember"/>
  <xs:element name="EmployeeWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_EmployeeWarrantsMember"/>
  <xs:element name="ExercisingOptionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ExercisingOptionMember"/>
  <xs:element name="ExternalMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ExternalMember"/>
  <xs:element name="FairmountHealthcareFundIILPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_FairmountHealthcareFundIILPMember"/>
  <xs:element name="FairmountMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_FairmountMember"/>
  <xs:element name="FairmountsOwnershipInterestInParagonMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_FairmountsOwnershipInterestInParagonMember"/>
  <xs:element name="FirstDosingOfHumanPatientInPhaseOneTrialMilestoneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_FirstDosingOfHumanPatientInPhaseOneTrialMilestoneMember"/>
  <xs:element name="MarketableSecuritiesCurrentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesCurrentMember"/>
  <xs:element name="MarketableSecuritiesLongTermMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesLongTermMember"/>
  <xs:element name="MarketableSecuritiesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesMember"/>
  <xs:element name="MarketableSecuritiesNoncurrentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_MarketableSecuritiesNoncurrentMember"/>
  <xs:element name="ORKAZeroZeroOneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ORKAZeroZeroOneMember"/>
  <xs:element name="ORKAZeroZeroTwoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ORKAZeroZeroTwoMember"/>
  <xs:element name="OperatingExpenseExcludingPersonnelRelatedAndStockBasedCompensationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OperatingExpenseExcludingPersonnelRelatedAndStockBasedCompensationMember"/>
  <xs:element name="OperatingExpenseExcludingStockBasedCompensationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OperatingExpenseExcludingStockBasedCompensationMember"/>
  <xs:element name="OrukaCommonStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OrukaCommonStockMember"/>
  <xs:element name="OrukaSeriesAConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OrukaSeriesAConvertiblePreferredStockMember"/>
  <xs:element name="OtherMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OtherMember"/>
  <xs:element name="OutstandingConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OutstandingConvertiblePreferredStockMember"/>
  <xs:element name="PIPEFinancingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PIPEFinancingMember"/>
  <xs:element name="ParagonMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonMember"/>
  <xs:element name="ParagonMilestonePaymentsForLicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonMilestonePaymentsForLicenseAgreementMember"/>
  <xs:element name="ParagonReimbursableOptionAgreementsFeesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonReimbursableOptionAgreementsFeesMember"/>
  <xs:element name="ParagonReimbursableOtherResearchExpensesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonReimbursableOtherResearchExpensesMember"/>
  <xs:element name="ParagonReimbursablePatentExpensesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParagonReimbursablePatentExpensesMember"/>
  <xs:element name="ParukaMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParukaMember"/>
  <xs:element name="ParukaWarrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParukaWarrantMember"/>
  <xs:element name="ParukaWarrantObligationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_ParukaWarrantObligationMember"/>
  <xs:element name="PreFundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PreFundedWarrantsMember"/>
  <xs:element name="PreMergerOrukaMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PreMergerOrukaMember"/>
  <xs:element name="PrefundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_PrefundedWarrantsMember"/>
  <xs:element name="RegulatoryMilestonesMemberMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_RegulatoryMilestonesMemberMember"/>
  <xs:element name="RestrictedStockAwardsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_RestrictedStockAwardsMember"/>
  <xs:element name="SeriesANonVotingConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesANonVotingConvertiblePreferredStockMember"/>
  <xs:element name="SeriesBConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesBConvertiblePreferredStockMember"/>
  <xs:element name="SeriesBNonVotingConvertiblePreferredStockAmountMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesBNonVotingConvertiblePreferredStockAmountMember"/>
  <xs:element name="SeriesBNonVotingConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesBNonVotingConvertiblePreferredStockMember"/>
  <xs:element name="SeriesBNonVotingConvertiblePreferredStockholdersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_SeriesBNonVotingConvertiblePreferredStockholdersMember"/>
  <xs:element name="StockOptionsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_StockOptionsMember"/>
  <xs:element name="TwoThousandTwentyFourEmployeeStockPurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_TwoThousandTwentyFourEmployeeStockPurchasePlanMember"/>
  <xs:element name="TwoThousandTwentyFourStockIncentivePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_TwoThousandTwentyFourStockIncentivePlanMember"/>
  <xs:element name="TwoZeroTwoFourEmployeeStockPurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_TwoZeroTwoFourEmployeeStockPurchasePlanMember"/>
  <xs:element name="USGovernmentAgencySecuritiesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_USGovernmentAgencySecuritiesMember"/>
  <xs:element name="OptionAgreementsAndLicenseAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_OptionAgreementsAndLicenseAgreementsAbstract"/>
  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="orka_DocumentAndEntityInformationAbstract"/>
</xs:schema>
